Endometrial Carcinoma types, symptoms, Causes and prevention - MedPGR

Endometrial Carcinoma types, symptoms, Causes and prevention

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Endometrial Carcinoma

Endometrial Carcinoma | Endometrial cancer
Endometrial Carcinoma

Endometrial carcinoma is cancer in females. In endometrial cancer, the cells of the lining of the female system (endometrial lining) undergo abnormal cell division. The cell starts to replicate rapidly in an uncontrol manner. Thus they form an unwanted mass that is called cancer.

Symptoms of Endometrial Carcinoma:

Symptoms show endometrial carcinoma in an early stage. If you think the following symptoms are shown in yourself you may have to consult your doctor.

Symptoms of Endometrial Carcinoma
Symptoms of Endometrial Carcinoma
  • Pain in the pelvic region
  • Viginal Bleeding  shown after the menopause
  • Painful and difficulty in the urination
  • Bleeding before the next period (between periods)
  • Weight loss
  • Hormonal imbalance

Causes of Endometrial:

The reason behind this is still unknown but many doctors think that endometrial carcinoma is developed by the mutation in the DNA. Thus cells start to be replicated uncontrolled and produce cancer in females.
Here are some risk factors that cause endometrial carcinoma:
  • Imbalance in the hormones of females like estrogen and progesterone.
  • The girls whose menstruation starts at an early age and the risk of endometrial carcinoma in such females increases.

Prevention from endometrial carcinoma:

If you get hormone therapy then consult your doctor. This condition is applied when you get hormone therapy after menopause. The use of contraceptive pills decreases the risk of endometrial carcinoma if you are using them for the last year. Many types of research show that females maintaining their weight in normal body weight have a rare chance of endometrial cancer.
If it is diagnosed at an early age then it is removed surgically and then it prevents ovary cancer. Therefore it needs to diagnose it in the starting and you must have to visit your doctor. Obesity is also one of the causes of Endometrial cancer. Women with hypertension have more chances to get this type of cancer. Mainly it is caused in old women after menopause. 

Two types of endometrial carcinoma?

Precursor

Hyperplasia

Serous endometrial

Intraepithelial carcinoma

Mutated genes /genetic abnormalities

PTEN,ARID1A,PIK3CA,

P13K,KRAS,FGF2,TP53

P53,ANEUPLOIDY,P13K,

FBXW7,CHD4PP2A

BEHAVIOUR

INDOLENT

SPREAD VIA LYMPHATICS

AGGRESSIVE

INTRAPENITONIAL AND LYMPHATIC SPREAD

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Caracteristics

Type 1

Type2

Clinical setting

Unopposed estrogen

 Obesity

 Hypertension

 Diabetes

Atrophy

 Thin physique

age

55-65 y

65-75y

morphology

endometrioid

Serous

Clear cell

Mixed müllerian tumor

References:

https://www.mayoclinic.org/diseases-conditions/endometrial-cancer/symptoms-causes/syc-20352461
https://www.healthline.com/health/endometrial-cancer
https://www.hopkinsmedicine.org/health/conditions-and-diseases/endometrial-cancer
https://www.cancer.gov/types/uterine/patient/endometrial-treatment-pdq
https://www.cancer.org/cancer/endometrial-cancer/detection-diagnosis-staging/signs-and-symptoms.html
https://www.webmd.com/cancer/understanding-endometrial-cancer-basics
https://www.medicalnewstoday.com/articles/266126
https://my.clevelandclinic.org/health/diseases/16409-uterine-cancer

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