Molar pregnancy - Complete and partial molar pregnancy - MedPGR

Molar pregnancy – Complete and partial molar pregnancy

Molar pregnancy

 Molar Pregnancy:

Molar Pregnancy
Molar Pregnancy

Molar pregnancy is a serious disease in which the fetus does not develop properly due to Changement in the chromosomes. There are two types of Molar pregnancy that are given below:

  1. Complete molar pregnancy
  2. Partial molar pregnancy
Types of  Molar Pregnancy

Complete molar pregnancy:

In the complete molar pregnancy the egg is fertilized by the father only and all the chromosomes 46 are contributed by the father only and the chromosomes of the mother do not participate, father’s chromosomes are duplicated, and that fertilizes the empty egg. Thus egg could not grow properly and the placenta develop abnormally just like fluid-filled cysts. This causes a spontaneous miscarriage of the fetus. Those cysts appear just like grapes.

Partial Molar Pregnancy:

In the partial molar pregnancy, the father contributes 46 chromosomes and the mother contributes 23 chromosomes that they make 69 chromosomes that change the cell functions. This happened when two sperm fertilize one egg. They both contribute their chromosomes. Thus abnormal tissue of the placenta forms and the fetus do not grow properly and cause the miscarriage of the fetus. In these females, abnormal villous enlargement occurs. 

methods of Complete and partial mole pregnancy

Chances of occurrence:

There is approximately 1 woman out of 1000 women is diagnosed with spontaneous miscarriage due to molar pregnancy. If someone is with molar pregnancy then it may have another molar pregnancy. The ratio of a repeat of such cases is 1 out of 100. The ratio of molar pregnancy is common in the females younger than 20 and those older than 35 of age. 

Cysts of Molar Pregnancy
Cysts of Molar Pregnancy

Treatment:

The molar pregnancy is normally removed by the curettage. If someone has molar pregnancy she could have to consult the doctor before the next pregnancy and get advice from the doctor, normally doctors do ultrasounds and exam the over and tell their patients for a gap of 6 months to 1 year after removing the molar pregnancy and many times it really works.
 

 

Complete Mole

Partial Mole

Clinical

Spontaneous miscarriage

Abnormal villous enlargement

Hcg level high

Spontaneous miscarriage

Abnormal villous enlargement

Hcg level high

Gross

Delicate

Friable mass of thin-walled

Translucent

Cyst

Grape like

Hydropic villi

Fraction of villi enlarge and edematous

Trophoblastic hyperplasia

 

Microscopy

Abnormal enlarge of all or some tissues villous

Chorionic villi are enlarged cisternae

Extensive trophoblastic proliferation

 

Fraction of villi enlarge and edematous

Trophoblastic hyperplasia

 

Fetal Parts

absent

Present swiss chese  appearance

P57 staining in cytotrophoblast

absent

positive

Treatment

Removal by curretage

Removal by curretage

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References:

https://www.mayoclinic.org/diseases-conditions/molar-pregnancy/symptoms-causes/syc-20375175
https://my.clevelandclinic.org/health/diseases/17889-molar-pregnancy
https://www.whattoexpect.com/pregnancy/pregnancy-health/complications/molar-pregnancy.aspx
https://www.thewomens.org.au/health-information/pregnancy-and-birth/pregnancy-problems/early-pregnancy-problems/hydatidiform-mole
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279094/
https://www.webmd.com/baby/what-is-molar-pregnancy

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